RARECHEM AL BE 1435
2-Bromo-5-thiazolecarboxylic acid
CAS: 54045-76-0
Molecular Formula: C4H2BrNO2S
RARECHEM AL BE 1435 - Names and Identifiers
| Name | 2-Bromo-5-thiazolecarboxylic acid |
| Synonyms | RARECHEM AL BE 1435 2-BROMOTHAIZOLE-5-CARBOXYLIC ACID 2-BROMO-5-THIAZOLECARBOXYLIC ACID 2-BROMOTHIAZOLE-5-CARBOXYLIC ACID 2-Bromo-5-thiazolecarboxylic acid 2-BROMO-5-THLAZOLECARBOXYLIC ACID 2-bromo-1,3-thiazole-5-carboxylate 2-Bromo-thiazole-5-carboxylic acid 2-BROMO-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-bromo-1,3-thiazole-5-carboxylic acid |
| CAS | 54045-76-0 |
| EINECS | 626-804-7 |
| InChI | InChI=1/C4H2BrNO2S/c5-4-6-1-2(9-4)3(7)8/h1H,(H,7,8)/p-1 |
| InChIKey | BESGTWHUMYHYEQ-UHFFFAOYSA-N |
RARECHEM AL BE 1435 - Physico-chemical Properties
| Molecular Formula | C4H2BrNO2S |
| Molar Mass | 208.03 |
| Density | 2.062±0.06 g/cm3(Predicted) |
| Melting Point | 182°C (dec.) |
| Boling Point | 350.0±15.0 °C(Predicted) |
| Flash Point | 165.5°C |
| Vapor Presure | 1.69E-05mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | White to off-white |
| pKa | 2.52±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD04115730 |
| Physical and Chemical Properties | 2-bromothiazole-5-carboxylic acid is white or gray-white crystalline powder at normal temperature and pressure, which belongs to thiazole derivatives and has certain acidity. |
RARECHEM AL BE 1435 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29341000 |
| Hazard Note | Irritant |
RARECHEM AL BE 1435 - Reference Information
| Uses | 2-bromothiazol-5-carboxylic acid can be used to prepare anti-inflammatory drugs, rubber accelerators, etc. In organic synthesis and conversion, the bromine unit on the thiazole ring can undergo arylation or alkylation reaction with aryl halides or alkyl halides through Suzuki coupling reaction; in addition, the carboxyl units in the structure can be converted into hydroxyl groups under the action of a reducing agent, or converted into ester groups or amide groups through condensation reactions. |
| synthesis method | cool diisopropylamine (0.77 ml, 10.61 mmol) in dry tetrahydrofuran to -20 degrees, slowly add n-butanol (6.2 ml) to the mixture, heat the resulting mixed system to 0 degrees, and stir the mixture at 0°C for 30 minutes in a nitrogen environment. Then cool the reaction mixture to -78°C, stir at -78°C for 30 minutes in a nitrogen environment, add 2-bromothiazole (0.17 ml, 12.5 mmol) tetrahydrofuran solution dropwise to the reaction mixture, and then continue to stir the reaction mixture at -78°C for 1 hour, add dry ice powder to the mixture, and stir the mixture at -78°C for 2 hours, hydrolyze the reaction mixture with water to raise the temperature of the reaction mixture. The reaction mixture was cleaned with DCM, the aqueous phase was acidified with 10% citric acid (pH = 3), the aqueous phase was extracted with ethyl acetate, the combined organic layer was dried with anhydrous sodium sulfate, and the combined organic layer was evaporated to dry to obtain the target product. Fig. 2-synthesis route of bromothiazol-5-carboxylic acid |
Last Update：2024-04-09 15:16:51
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RARECHEM AL BE 1435
6-吡啶二甲酸二乙酯
氯丙烷
聚(乙二酸新戊二醇酯
甲基二苯基氯硅烷
环氧丙氧基丙基封端的聚二甲基硅氧烷
1-癸基-3-甲基咪唑三氟甲烷磺酸盐
Β-哌啶子基苯丙酮
异丁烯酸环己酯
2-CARBOXYETHYL ACRYLATE
6-吡啶二甲酸二乙酯
氯丙烷
聚(乙二酸新戊二醇酯
甲基二苯基氯硅烷
环氧丙氧基丙基封端的聚二甲基硅氧烷
1-癸基-3-甲基咪唑三氟甲烷磺酸盐
Β-哌啶子基苯丙酮
异丁烯酸环己酯
2-CARBOXYETHYL ACRYLATE